Biological evaluation and molecular modelling of didanosine derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis, Radiolabeling and Biological Evaluation of 99mTc-labeled Deoxyglucose Derivatives for Molecular Imaging
Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [99mTc(H2O)3(CO)3]+ complex. [99mTc]-ECB-DG and [99mTc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na99mTcO4 in 1 mL saline. Radi...
متن کاملSynthesis, Radiolabeling and Biological Evaluation of 99mTc-labeled Deoxyglucose Derivatives for Molecular Imaging
Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [99mTc(H2O)3(CO)3]+ complex. [99mTc]-ECB-DG and [99mTc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na99mTcO4 in 1 mL saline. Radi...
متن کاملDesign, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents
A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...
متن کاملDesign, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents
A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...
متن کاملsynthesis, radiolabeling and biological evaluation of 99mtc-labeled deoxyglucose derivatives for molecular imaging
two deoxyglucose (dg) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-d-glucose (ecb-dg) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-d-glucose (dhp-dg), were synthesized and radiolabeled successfully with [99mtc(h2o)3(co)3]+ complex. [99mtc]-ecb-dg and [99mtc]-dhp-dg complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mci of na99mtco4 in 1 ml saline. radi...
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ژورنال
عنوان ژورنال: Med. Chem. Commun.
سال: 2014
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c4md00003j